Another dominant home performance by the host saw them put six goals past an unimpressive Arsenal side and cut down their lead on the EPL summit to just 2 points.
The host started the match the stronger of both side and were duly rewarded in the 13th minute when Aguero converted Demichlis's near post flick from a corner kick.
The duel was set and Arsenal equalized after 31 minutes when Yaya Toure gifted the gunners possession in his own half, allowing the visitors to stage an immediate counter with returnee Walcott converting.
However, Arsenal's moment was short-lived as Negredo helped his side regain the lead in the 39th minute, scoring from point-blank range. Matters worsened for Arsenal as Laurent Koscielny sustained an injury and had to come of for Vermaelen.
Aguero was next to be withdrawn right at the beginning of the second half but it was not a hindrance to the host who added another goal when Fernandinho benefitted rom a sloppy Arsenal defending to curl a beautiful strike past Szczesny.
Wenger's men refused to give up and were soon rewarded for their resilience with Theo Walcott's second for the afternoon as the winger bended a wicked ball into the far corner.
There was no stoping this City side however as Silva restored their two-goal lead with a one-touch effort from Navas's cross.
The host who have made their home ground a fortress sort for a fifth with Nasri throwing many opportunities away but Man of the Match Fernandinho grabbed his second in the 88th minute after a nice footwork to beat Szczesny.
Arsenal grabbed a consolation goal through Mertesacker after poor defending from City but the host weren't done yet as Yaya Toure scored from the spot after Milner was brought down in the box by Szczesny.
The league leaders title credentials have been handed a heavy blow and their critics will have a filled day in assessing what has been an uninspiring performance from the Londoners.
